Category: News

 

This is clearly the most common, new-gen iteration of the STUNT concept invented by FIVE. Its topside construction in tough stretch Twill Span fabric contributes greatly to the exceptional comfort of this iconic style. It features exceptional protection, given the second-skin feel it offers, with its AirgoProtech™ shells inspired by helmet technology (see previous pages), featuring a particularly innovative design. Its 100% full-grain goat leather palm, which is both supple and durable, feels so smooth and soft to the touch…And yet, it offers excellent grip on the controls and hosts a leather reinforcement lined with an ERGO PROTECH® semi-soft, honeycombed protective shell that offers a reassuring feeling of safety, without hindering your movements in any way. With its signature look, the STUNT EVO2 offers its rider a certain kind of status: that of an avant-garde design aficionada, even offering the feeling of being truly on the cutting edge, even ahead of the curve.

 

FEATURES

• Twill Span stretch topside construction
• Full-grain goat leather palm 
• Ventilated AirgoProtech™ metacarpal-knuckle protector 
• ERGO PROTECH® honeycombed palm slider
• TPR finger protection with air intake vent
• Softshell thumb construction for optimal finesse and comfort
• Ultra-tough stretch Nylon fourchettes between the fingers
• Ergonomic, fused neoprene wristband with integrated velcro closure
• Touch Screen™ system on the index finger and thumb
• CE KP1

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Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products

William M. Hewitt, Siegfried S. F. Leung, Cameron R. Pye, Alexandra R. Ponkey, Maria Bednarek, Matthew P. Jacobson, and R. Scott Lokey, J. Am. Chem. Soc., 2015, 137, 715-721.

Drug design efforts are turning to a new generation of therapeutic targets, such as protein–protein interactions (PPIs), that had previously been considered “undruggable” by typical small molecules. There is an emerging view that accessing these targets will require molecules that are larger and more complex than typical small molecule drugs. Here, we present a methodology for the discovery of geometrically diverse, membrane permeable cyclic peptide scaffolds based on the synthesis and permeability screening of a combinatorial library, followed by deconvolution of membrane-permeable scaffolds to identify cyclic peptides with good to excellent passive cell permeabilities. We use a combination of experimental and computational approaches to investigate structure-permeability relationships in one of these scaffolds, and uncover structural and conformational factors that govern passive membrane diffusion in a related set of cyclic peptide diastereomers. Further, we investigate the dependency of permeability on side-chain identity of one of these scaffolds through single-point diversifications to show the adaptability of these scaffolds toward development of permeability-biased libraries suitable for bioactivity screens. Overall, our results demonstrate that many novel, cell permeable scaffolds exist beyond those found in extant natural products, and that such scaffolds can be rapidly identified using a combination of synthesis and deconvolution which can, in principle, be applied to any type of macrocyclic template.

Description

DESCRIPTION
Fresh flavor of cucumber and black pepper with a nicotine level of 14 milligrams per gram.

FACTS
Weight: 16,8 grams
Flavour cucumber and black pepper
Nicotine Level: 14 mg/g
Pouch size: slim
Number of pouches: 24
Texture: moist
Available: in single cans, rolls (10 cans)
Manufacturer: BAT

Botrytis is an airborne fungal disease that can affect all flower, fruit and vegetable tissues. Starting as a little while speck on the flower petals, it spreads right to the bottom of the flower. It gradually changes its colour to brown and finally all the petals fall off.

Botrytis blight or “gray mold” is a widely distributed disease caused by the fungus Botrytis species. Botrytis is an airborne fungal disease that can affect all flower, fruit and vegetable tissues. Starting as a little while speck on the flower petals, it spreads right to the bottom of the flower. It gradually changes its colour to brown and finally all the petals fall off.

Peonies and Roses are the most likely plants to show signs of botrytis. Other flowers, such as Chrysanthemum, Gerbera and Lisianthus are also very attractive to the Botrytis fungi.

Unfortunately, horticulturists haven’t developed any botrytis-resistant flower species. Gardeners must continue to battle this tenacious fungal flower disease by practicing good garden and greenhouse hygiene and cultural practices.

To minimize botrytis:

1. Keep your flowers dry (the buds and petals). Do not spray water or allow water to drip onto the Flower heads
2. Remove infected flower petals  or the entire bud and stem when required. This will keep botrytis from spreading to the rest of the flowers in a vase or arrangement.
3. Do not leave flowers in their sleeve or wrap any longer than necessary. If condensation builds up in the sleeve or wrap, open the bunch, wipe moisture off of wrap, fluff up the blooms and allow them to dry a bit before re-wrapping.
4. Keep good air circulation

When discussing fresh cut flowers and how to help them reach their maximum potential an extremely critical part of the cycle are the methods and techniques of Post-Harvest Care that are used starting at the time of cut. Too often flowers are harvested at the farms and transported to retail outlets only to be subjected to poor or non-existent post-harvest care when they arrive.

Strict adherence to the latest in Post-Harvest Care methods and treatments is a must. Fresh Cut Flowers prefer a clean environment and require proper nourishment, under these conditions they flourish.

Guest posting or guest blogging is a Search Engine
Optimization (SEO) practice of writing an article on other people’s websites or
blogs. The purpose is to build links and gain exposure to your own websites and
blogs.

.

Using guest posting is said to be one of the best ways to
build links these days. The guest post is no different from any other content
on the site so the links in the posts won’t be discounted as spam link.

.

In this article, we’re going to talk about some important
things related to guest posting from finding the sites to publish your content
on and to writing the pitches.

Finding sites that work for you

The best sites for guest posting are sites within the same niche
as your own. It doesn’t have to be an exact match but the closer the better. For
instance, if you have a blog about sugar gliders, then look for blogs and
websites covering small pets.

.

“Are free guest posting sites any good?”

.

No! Stick to real sites and not sites built and dedicated
for the sole purpose of guest posting. Sites where everyone is welcome end up
getting too similar to link farms. Google has discounted the value of links
from those sites eons ago. In the worst case, Google will kick your site to
oblivion. Just stay away.

.

“What about PBN?”

A Private Blog Network (PBN) is a collection of websites
created for the sole purpose of link building. Small networks may contain ten
or twenty sites but the big ones can have more than a thousand. You pay a set
amount for your articles plus links to appear on those PBN sites. On some
networks, you have to pay an annual fee for your links to stay on.

.

PBNs worked like magic in the past. Even for new sites,
achieving first page rankings for tough keywords in under three months was
possible. Search engines hate PBNs and consider them as a form of link
spamming. For years, such networks have flourished and demolished over and over
again.

.

Tips for writing guest post pitches

Once you find the perfect site, it’s time to prepare your
pitch. Make sure your email goes straight to the point. Also make sure your
email focuses on the benefits. Why would
website owners let you write for them? Why would they link to some unknown
website? How useful is your article for their website audience? If you can’t
give a clear answer to those questions, then don’t even bother emailing.

.

In addition, do your best to be personal when writing the email. Using an email template for
your pitches is fine as long as you personalize each one. If you think simply
changing the name of the website plus the admin is enough, think again. If
you’re too busy to customize the pitches, don’t blame the site owners for being
too busy to read them.

.

All things said, don’t be discouraged if you get rejected.
Keep trying with the other websites in your list and don’t nag the same owner
or admin of the sites that rejected you.

.

“The admin says go ahead. Now what?”

.

Now it’s time to deliver the article. Keep in mind that different
websites have different needs and preferences.
One site may prefer how-to articles while others may prefer comparisons between
products and services. It’s best if you check each website then identify what
kind of content works best for each.

.

Do note that articles that are too generic won’t do. Your
article my provide value and should be as unique as possible. Also remember to double-check the article before
you send it to the webmaster. If it’s plagued with spelling errors, your
article will go straight to the trash.

本教程适用版本：WPS 365 点击免费使用

如果我们想清除文本中的多余空格时，这时通常都会用到TRIM函数。TRIM 函数的作用是删除字符串首尾的空格，但会保留字符串内部词与词之间分隔的空格。

举个例子，比如我们要清除A2单元格内文本首位的空格字符。操作方法如下：

￭ 首先，选中B2单元格，点击插入函数，找到TRIM函数，然后点确定。

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￭ 然后，我们选中A2填入字符串内，这时可以看到填入时字符串首尾都有未去除的空格。

点击确定，去除首尾空格后的结果就显示出来了，不过词与词之间的空格会被保留。

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今天，明尼苏达森林狼队的官方社交媒体展示了10套代表球队不同历史阶段的球衣。

其中不乏2021-22赛季的城市版球衣，今年的复古球衣以及森林狼加内特时期的经典主客场球衣等。

森林狼官方发问：你最喜欢历史上森林狼的哪套战袍?

Description

LOOP Red Chili Melon Hyper Strong – This will gice you a fresh taste of Red Chili to give you that hot zing, combined with that sweet Watermelon. This is a pouch that will last and keep you fresh, in slim portions that will fit discreetly under your lip. This is an Hyper strong pouch with a nicotine level of 20 milligrams per gram.

FACTS

Net Weight: 13,75 g
Flavor: Red Chili, Water Melon
Nicotine: 25 mg/g ( 15,6 mg per pouch )
Pouch size: Slim
Number of pouches: 22
Texture: Moist
Available in: Single cans, Rolls (10 cans)
Manufacturer: Another Snus Factory

本教程适用版本：WPS 365 点击免费使用

在EXCEL的单元格中，有些单元格为填写的不是数值，在某些情况下，会影响计算结果，例如，以下的表格中，红框内的单元格一个是输入了一个空格，另一个“—”符号，后面平均值的计算未将该单元格计算在内，得出的平均值并不符合日常需求。今天我们将学习一个技巧，如何用ISNUMBER判断是否是数值：

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第一步，我们来认识下ISNUMBER函数——ISBLANK(VALUE)，从该表达式中可以看出该函数包含1个参数，这个参数value表示需要进行检验的内容。由于该函数的返回值为逻辑值，所以在使用此函数时如果参数为数值则返回TRUE，如果参数为非数值，则返回FALSE。

第二步，我们需要判断两个单元格，我们通过and函数和ISNUMBER组合进行判断，在E2单元格中输入公式【=AND(ISNUMBER(B2),ISNUMBER(C2))】，下拉填充剩余单元格：

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最后，在第二行和第四行就显示出为【FALSE】，表示这一行有非数值单元格。通过将非数值单元格调整为数值0，即可求出平均销量：

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至此，用ISNUMBER判断是否是数值就完成了，大家学会了吗？