Josh Mart takes the opportunity to preview Paris Saint Germain’s final Champions League match of 2016 at home against Bulgarian sides Ludogorets Razgrad.

The French Champions managed to secure a hugely important 2-2 away at Arsenal last time around, a result means that PSG have all but secured top spot in Group A, unless they fail to match the Gunners result here of course.

The performance of the team at the Emirates was had its positives and negatives, although Unai Emery will be delighted and somewhat relieved to see his side sit at the top of the table ahead of the final matchday.

Ludogorets still have hope of making it into 3rd place, which means a shot at the Europa League in the New Year. They simply need to match Swiss side Basel’s result against Arsenal, no matter the final score, as the Bulgarians have the better head to head ratio which would see them finish in third position.

PSG’s domestic form has been troubling to say the least for coach Unai Emery. Despite four of their last five matches in Ligue 1, Les Parisiens sit in 3rd place in the standings as we head towards France’s winter break.

The good run of form of late as abruptly halted by a resounding 3-0 defeat at Montpellier in the south of France on Saturday. PSG are 4 points behind surprise package Nice, and have thrown in shock results such as the one against Montpellier far to regularly this season.

Ludogorets have been in superb form of late in the Bulgarian First League and they currently sit six points clear of second placed Levski Sofia and with a game in hand. Last Wednesday’s 2-1 win against the aforementioned Levski was Ludogorets’ twelfth win in a row in the league competition, so their confidence will be extremely high right now.

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Team News and Tactics

Unai Emery has a few selection headaches ahead of this match at the Parc des Princes. The match against Arsenal was a costly one for Marco Verratti, he scored a very unfortunate own goal and got himself suspended for this final match up so PSG will be without him. Elsewhere, Javier Pastore and Adrien Rabiot are missing through injury.

With this in mind, I expect PSG to lineup in their usual 4-3-3 formation with Areola between the posts, Aurier who missed the Arsenal trip through visa issues is expected to regain his place at right back. Marquinhos, Thiago Silva and Maxwell are expected to make up the rest of the back four.

With Verratti missing, I would imagine Matuidi will drop back into midfield alongside Thiago Motta and probably Krychowiak, although Emery could opt to play the more attacking Hatem Ben Arfa instead with Di Maria dropping into midfield.

The front three will of course be spearheaded by Edinson Cavani and he is likely to be supported by Lucas and Di Maria. Unai Emery could decide to play a couple of youngsters like Nkunku or Kimpembe, but with the win still needed, I think we will see them from the bench if at all.

Ludogorets have just the one major injury concern; Vitinha will miss out through a knee injury here.

With this in mind I expect coach Dermendzhiev to set his side out in a quite narrow 4-2-3-1 formation with Stoyanov in goals. Protecting him will likely be Palomino and Moti at the heart of the defence, with Cichinho and Natanael the full backs. Dyakov and Andrianantenaina are set to start in front of the back.

The talented front 4 for Ludogorets is why they have caused teams problems in the past and I think Dermendzhiev will opt to play Misidjan, Cafu and Wanderson are likely to start behind Keseru in attack, although Lukoki or Marcelinho could replace one of the advanced 3 midfielders if necessary.

Danger Men

Lucas Moura (PSG) – In a side which can occasionally lack pace and directness in attack, Lucas Moura provides it in abundance. He is very skilful and can also provide assists for his team mates.

His headed goal at the Emirates a few weeks ago was a surprise, but he undoubtedly has the talent and desire to notch against the Bulgarians here tonight.

Misidjan (Ludogorets) – Virgil Misidjan or ‘Vura’, as he likes to be known, was once labelled a potential top talent when he broke through the ranks of local club Willem II in Holland in 2012 but his move to Ludogorets was considered by most a bad choice for a promising young winger.

However, Misidjan has performed well over the 3 years or so that he has played in Razgrad, and he has the pace and trickery to cause PSG problems at the Parc des Princes.

Prediction

Tonight’s match is one that PSG should win and I think they will. The Bulgarians caused both PSG and Arsenal some problems on home soil, but I think the trip to Paris will be one step too far for Ludogorets. The home side need the three points to make top spot theirs and I expect them to be comfortable winners here.

Prediction: PSG 3-0 Ludogorets

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According to our colleagues at Foot 365, Hebei China Fortune attacking midfielder Ezequiel Lavezzi’s entourage is in talks with OGC Nice.

Les Aiglons are looking to potentially bring the former PSG man on a 6 month loan deal.

When asked about the rumours in a press conference today, OGC Nice manager Lucien Favre claimed he was unaware of any talks:

“I am not aware. He is a good player… he would create an atmosphere in the dressing room.”

Ezequiel Lavezzi is understood to be seeking an exit door from China to return to Europe for the second half of the season as he seeks more regular and competitive game time.

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M231

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Polyester

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Adults, Children

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In the furore surrounding the incidents in Metz on Saturday, it may have been easy to forget that what is Lyon’s biggest match of the season takes place this evening at the Parc OL.

Defeat Sevilla by two goals or more and Lyon are through to the knockout stages of the Champions’ League for the first time in five years. Any other result sees them drop into the Europa League, a result which, while disappointing, still comes on the back of two of the club’s most impressive performances.

Going toe-to-toe with Juventus was hardly to be expected given the way the club had capitulated against Sevilla at the Pizjuan, but the point earned in Turin was enough to make this match matter after the Bianconeri did Lyon a favor by winning 3-1 in Spain.

Team News:

Lyon have nearly a full complement of players available to them, as Anthony Lopes, the primary victim in Saturday’s incident, has returned to training. Likewise young centre back Emanuel Mammana, who has brushed off a thigh injury and could see a place on the bench owing to his lacking match fitness.

Christophe Jallet is still a miss at right back, but otherwise the team is fully fit, and the only questions surround how Bruno Genesio will set the team up.

The team had played an expansive double pivot system in the second half against Paris Saint-Germain, turning in one of their more coherent attacking performances in the process. Needing to score, Genesio should do well to progress with that system. Lopes should start in goal if training yesterday wasn’t an issue, with a back four of Rafael, Mapou Yanga-Mbiwa, Mouctar Diakhaby and Jérémy Morel.

Maciej Rybus could supplant the former Marseille man at left back, but with Rafael more likely to be getting forward in attack, Genesio will crave the solidity that the veteran brings. Corentin Tolisso and Maxime Gonalons will be in central midfield, with Mathieu Valbuena and Rachid Ghezzal in wide areas.

Nabil Fekir was rested against Metz, and he should partner Alexandre Lacazette in a slightly withdrawn role. There is a small chance Genesio could opt for a 4-3-3 with one of Sergi Darder or Jordan Ferri in and Fekir, Ghezzal or Valbuena dropping to the bench, but the manager should opt to have as many goal-scoring options on the pitch as possible.

Sevilla have a similarly empty treatment table, although Fran Vazquez is suspended after being sent off against Juventus and Dani Carrico is unlikely to feature owing to a thigh injury, while former Bordeaux man Benoit Tremoulinas is a long-term absence.

Even though we have a fairly solid idea of the personnel available to manager Jorge Sampaoli, guessing how he will deploy them is another matter. A draw is enough to secure progression, but a win could see Sevilla top the group on 13 points if Juventus should stumble against Dinamo Zagreb.

Sergio Rico is a given in goal, and a nominal 4-2-3-1 makes the most sense, especially given the propensity of the fullbacks to get forward, but a three-man defence could also be deployed, as it provides more solidity in central areas without sacrificing the attacking intent of the full-backs.

If the latter is the case, Adil Rami, who missed the reverse fixture, will start alongside Nicolas Pareja and Gabriel Mercado, with Timothée Kolodziejczak a candidate as well.

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Mariano and Sergio Escudero, who was magnificent when these team met earlier, would be wing-backs, with a midfield of Steven N’Zonzi, Vicente Iborra and Samir Nasri.

Vitolo would then play off of one of Luciano Vietto or Wissam Ben Yedder. The Argentine was profligate against Lyon earlier, but has been more decisive in the league of late.

That said, Ben Yedder may be a better option given his ability to stretch play on the counter. Sampaoli himself was elusive about his eleven in yesterday’s pre-match press conference, acknowledging the different abilities of the pair and saying the it was a decision he was yet to make.

However he sets his side up, Sevilla, who sit third in La Liga, are still a dangerous opponent, and Lyon will do very well to get the result that they need.

Danger Men:

Mathieu Valbuena, Olympique Lyonnais

Rested against Metz at the weekend, “Le Petit Velo” has been incandescent of late, scoring against Paris Saint-Germain and delivering a man-of-the-match performance against Nantes a week ago.

Misused tactically upon arriving in Lyon and suffering under the emotional weight of being a former Marseille player and his sex tape scandal, Valbuena rarely demonstrated his considerable capabilities last season. This campaign has been marred by injury, and he is only recently back to full fitness.

Playing on the left of a 4-3-3, his preferred system, his dribbling ability and passing have been top-drawer, and with Rachid Ghezzal similarly stretching play on the opposite flank, Lyon have finally showed themselves to be a capable attacking side.

With at least two goals needed against Sevilla, if Les Gones are to have any hope of progression, Valbuena will have to be back to his incisive best.

Steven N’Zonzi, Sevilla FC

N’Zonzi has always been a player of some quality, having impressed during his time at Stoke City. He was also an integral part of Sevilla under Unai Emery’s management as well, but under Jorge Sampaoli, he has blossomed, even being discussed for the national side.

Given the competition for places under Didier Deschamps, that is still an unlikely scenario, but is a testament to his energy and work rate. Against Lyon in the reverse fixture, and often in La Liga, N’Zonzi has been a one-man wrecking crew in midfield, his endless running covering the ground two or three players would.

This has allowed Sevilla to play with not only a slew of attacking midfielders but also see the fullbacks bomb on as well.

It may seem reckless to play with only one defensive midfielder and two centre backs as orthodox defensive players, but the way N’Zonzi can control a midfield means that the club’s performances have rarely suffered.

Score Prediction: Olympique Lyonnais 2-1 Sevilla FC

E.D.

Premier League side Southampton have made an enquiry for PSG’s French international central defender Presnel Kimpembe, according to our colleagues at L’Équipe.

The Saints appear to be activating back up plans for the possible departures of either José Fonte or Virgil van Djik. However, there is virtually no chance of Kimpembe joining Claude Puel’s men next month, as he is currently PSG’s third and only other choice at centre-back behind Marquinhos and Thiago Silva.

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Premier League side Liverpool will seek to offload French central defender Mamadou Sakho his January.

According to Yahoo Sport journalist Manu Lonjon, Liverpool could accept an offer as small as €15m next month in order to part with the player.

West Brom, who attempted to sign him in the summer, have cooled their interest somewhat.

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The journalist in question claims that a number of other unnamed English clubs are lining up a possible move.

For over a century, researchers have known about “the bends”, a serious condition affecting scuba divers. However, we still know relatively little about its physiological basis. Doctors do not yet have a definitive test for the bends, instead relying on symptoms to diagnose it. A new study in Frontiers in Physiology is the first to investigate genetic changes in divers with this condition, finding that genes involved in inflammation and white blood cell activity are upregulated. The findings cast light on the processes underlying the bends, and may lead to biomarkers that will help doctors to diagnose the condition more precisely.

The bends, more formally known as decompression sickness, is a potentially lethal condition that can affect divers. Symptoms include joint pain, a skin rash, and visual disturbances. In some patients, the condition can be severe, potentially leading to paralysis and death.

Researchers have known about the condition for a long time. A paper published in 1908 correctly hypothesized that it involves bubbles of gas forming in the blood and tissue because of a decrease in pressure. However, despite this, researchers do not yet fully understand the precise mechanisms underlying the condition. Animal studies have suggested that inflammatory processes may have a role in decompression sickness, but no-one had studied this in humans.

Divers have developed methods to reduce the risk of the bends, including controlled ascents from the depths, and it is now relatively rare. However, for suspected cases, doctors have no way to test for the condition, and instead rely on observing symptoms and seeing whether patients respond to hyperbaric oxygen therapy, which involves breathing oxygen at high pressures.

To investigate the basis of decompression sickness, the researchers behind this new study took blood samples from divers who had been diagnosed with decompression sickness and divers who had completed a dive without developing the condition. The researchers took blood samples at two distinct times: within 8 hours of the divers emerging from the water, and 48 hours afterwards, when the divers with decompression sickness had undergone hyperbaric oxygen treatment. They performed RNA sequencing analysis to measure gene expression changes in white blood cells.

“We showed that decompression sickness activates genes involved in white blood cell activity, inflammation and the generation of inflammatory proteins called cytokines,” explained Dr. Nikolai Pace of the University of Malta, a researcher involved in the study. “Basically, decompression sickness activates some of the most primitive body defense mechanisms that are carried out by certain white blood cells.”

Interestingly, these genetic changes had diminished in samples taken at 48 hours after the dive, after the patients had been treated with hyperbaric oxygen therapy. The findings provide a first step towards potentially developing a diagnostic test for decompression sickness, and may also reveal new treatment targets.

“We hope that our findings can aid the development of a blood-based biomarker test for human decompression sickness that can facilitate diagnosis or monitoring of treatment response,” said Prof Ingrid Eftedal of the Norwegian University of Science and Technology, who was also involved in the project. “This will require further evaluation and replication in larger groups of patients.”

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Citation:
Molecular changes in white blood cells can help diagnose ‘the bends’ earlier in divers (2021, June 10)
retrieved 10 December 2024
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Women who suffer from fibromyalgia benefit from a treatment regimen in a hyperbaric oxygen chamber, according to researchers at Rice University and institutes in Israel.

A clinical trial involving women diagnosed with fibromyalgia showed the painful condition improved in every one of the 48 who completed two months of hyperbaric oxygen therapy. Brain scans of the women before and after treatment gave credence to the theory that abnormal conditions in pain-related areas of the brain may be responsible for the syndrome.

Results of the study appear in the open-access journal PLOS ONE.

Fibromyalgia is a chronic pain syndrome that can be accompanied by – and perhaps related to – other physical and mental conditions that include fatigue, cognitive impairment, irritable bowel syndrome and sleep disturbance.

More than 90 percent of those diagnosed with the syndrome are women, said Eshel Ben-Jacob, a lead author of the proof-of-concept study who developed the analytical method used to show the association between patients’ improvement and changes in their brains. He is an adjunct professor of biosciences at Rice University, a senior investigator at Rice’s Center for Theoretical Biological Physics and a professor of physics and member of the Sagol School of Neuroscience at Tel Aviv University.

“Symptoms in about 70 percent of the women who took part have to do with the interpretation of pain in their brains,” Ben-Jacob said. “They’re the ones who showed the most improvement with hyperbaric oxygen treatment. We found significant changes in their brain activity.”

Scientists have not pinned down the syndrome’s cause, although another recent PLOS One study identified a possible RNA-based biomarker for its diagnosis. A variety of treatments from drugs to lifestyle changes have been tried to relieve patients’ suffering, with limited success, Ben-Jacob said.

“Most people have never heard of fibromyalgia,” he said. “And many who have, including some medical doctors, don’t admit that this is a real disorder. I learned from my M.D. friends that this is not the only case in which disorders that target mainly women raise skepticism in the medical community as to whether they’re real or not. However, these days there are increasing efforts to understand the effect of gender on body disorders.”

Researchers at the Sagol Center for Hyperbaric Medicine and Research at the Assaf Harofeh Medical Center and Tel Aviv University were studying post-traumatic brain injury patients when they realized hyperbaric oxygen treatment (HBOT) could help patients with fibromyalgia.

“Patients who had fibromyalgia in addition to their post-concussion symptoms had complete resolution of the symptoms,” said Dr. Shai Efrati, who noted his own mother suffers from the syndrome. Efrati is lead author of the study, head of the research and development unit at the Assaf Harofeh Medical Center and a member of the Sagol School of Neuroscience at Tel Aviv University.

Hyperbaric oxygen chambers that expose patients to pure oxygen at higher-than-atmospheric pressures are commonly used to treat patients with embolisms, burns, carbon monoxide poisoning and decompression sickness (known to divers as “the bends”), among many other conditions.

One effect of exposure is to push more oxygen into a patient’s bloodstream, which delivers it to the brain. Efrati’s earlier trials found HBOT induces neuroplasticity that leads to repair of chronically impaired brain functions and improved quality of life for post-stroke and mild traumatic brain injury patients, even years after the initial injury.

Ben-Jacob said two patients spearheaded the push for the study. One was an Oxford graduate student who developed fibromyalgia after suffering a traumatic brain injury in a train crash. “By chance, the secretary of the department where she worked is the mother of the nurse in charge of the HBOT. She said you have to go and try to do it,” he recalled.

The other, he said, is a professor of sociology who specializes in post-traumatic stress disorders due to child abuse. The professor had suffered from fibromyalgia for many years. Her symptoms got worse through the initial treatments – a common experience for other patients in the study who she said had suppressed memories due to child abuse – before they got better. But by the end of treatment both women showed remarkable improvement, Ben-Jacob said.

Efrati said some patients will likely require follow-up sessions. “The abnormalities in brain regions responsible for the chronic pain sensation in fibromyalgia patients can be triggered by different events,” he said. “Accordingly, the long-term response may be different.

“We have learned, for example, that when fibromyalgia is triggered by traumatic brain injury, we can expect complete resolution without any need for further treatment. However, when the trigger is attributed to other causes, such as fever-related diseases, patients will probably need periodic maintenance therapy.”

The clinical trial involved 60 women who had been diagnosed with fibromyalgia at least two years earlier. A dozen left the trial for various reasons, but half of the 48 patients who completed it received 40 HBOT treatments five days a week over two months. Half of the 48 patients who completed the trial received 40 HBOT treatments five days a week over two months. The 90-minute treatments exposed patients to pure oxygen at two times the atmospheric pressure.

The other half were part of what Ben-Jacob called a crossover-control group. They were evaluated before the trial and after a control period that saw no improvement in their conditions. After the two-month control, they were given the same HBOT treatment as the first group and experienced the same relief, according to the researchers.

The researchers noted the successful treatment enabled patients to drastically reduce or even eliminate their use of pain medications. “The intake of the drugs eased the pain but did not reverse the condition, while HBOT did reverse the condition,” the researchers wrote.

Efrati said the findings warrant further study. “The results are of significant importance since, unlike the current treatments offered for fibromyalgia patients, HBOT is not aiming for just symptomatic improvement,” he said. “HBOT is aiming for the actual cause—the brain pathology responsible for the syndrome. It means that brain repair, including even neuronal regeneration, is possible even for chronic, long-lasting pain syndromes, and we can and should aim for that in any future treatment development.”

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Citation:
Hyperbaric hope for fibromyalgia sufferers (2015, June 2)
retrieved 10 December 2024
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part may be reproduced without the written permission. The content is provided for information purposes only.

Manchester United attacker Anthony Martial is unhappy with his current situation at the Red Devils, according to L’Équipe.

The player, who did not feature in Manchester United’s victory over West Ham United, wants to receive more playing time and there is a feeling that the enormous fee that the Red Devils paid for him is not being reflected in his current importance to Mourinho’s outfit.

Martial is one of the most highly sought after attackers on the European market today. Sevilla and West Ham United have had loan approaches rejected by Manchester United, with Mourinho keen to keep the French international on for the rest of the season in his current bit-part role.

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