Pablo Exclusive Strawberry Lychee 50mg

Description

Pablo Exclusive Strawberry Lychee 50mg – This is a breathtaking product of the Pablo line that is famous for its combination of killer power and pleasant sweetness. A combination of sweet flavors from strawberries and  lychee with a refreshing cooling feeling.

FACTS

Weight: 12 gram (net)
Flavour: Strawberry Lychee
Nicotine: 50 mg/g ( 30 mg per pouch)
Pouch size: Slim
Pouch Weight: 0,6 g
Number of pouches: 20
Texture: Moist
Available in: Single cans, Rolls (10 cans)
Manufacturer: UAB N.G.P. Empire Lithuania

Keyword: nicotine pouches

Top 3 Effects of Globalization on Manufacturing

There are tremendous new opportunities opening up for product developers, entrepreneurs and manufacturers around the world due to the increasing pace of globalization. Here are, in our opinion, the top three effects globalization is having on manufacturing and how our team thinks manufacturers should deal with them.

1. Trade Agreements

Free trade agreements can be beneficial to both manufacturers and consumers in the participating nations by opening access to markets and goods. If you happen to be sourcing from a supplier located within a trade zone favorable to you, this may be a great chance to save money by avoiding import duties, as is the case with agreements like the new CHAFTA legislation between China and Australia.

But such agreements are also subject to sudden changes due to political and market forces over which both consumers and suppliers have no control. A business relationship that was a great deal yesterday may suddenly be upended overnight if tariffs increase, certain commodities are blocked, or currency valuations fluctuate dramatically – all very real possibilities in a global economy. Is there a way you can protect yourself in the long-term?

Your best bet is to always work with companies that represent lasting value based on sound management principles. This means low-overhead, high quality and fast response times. Business cycles come and go, and trade agreements sometimes work for you one day and against you another. But if you stick with manufacturing companies that provide universally valuable service and delivery you’ll always come out ahead in the long run.

2. Environmental Regulations

As with free trade agreements, international treaties have been drawn up to join nations together to address pollution, resource depletion and climate change.

The best global companies don’t see environmental protection as a regulatory burden and neither should you. Rather, try to work with manufacturers that treat environmental responsibility as part of their core business practice. This involves asking about the following:

  • Have they upgraded their machinery and equipment whenever possible to be more efficient while making a smaller carbon footprint?
  • Have they streamlined their procedures to reduce waste and unnecessary or repetitive work?
  • Do they recycle, re-use or up cycle materials to keep them out of the waste stream, which also reduces material costs?
  • Have they partnered with independent, third-party certification bodies like ISO to document and maintain high standards for health, safety and environmental controls?
  • Have they replaced hazardous or non-biodegradable supplies with “green” alternatives?

Companies using best practices for environmental management are sure to demonstrate the same kind of due diligence in managing the rest of their business, so this is a great way to find a manufacturing partner that is not only green but also dedicated to employing world-class standards in all of their operations.

3. Responsible Sourcing

Because of globalization, raw materials are routinely sourced from, and shipped to, many places around the world. As the supply chain extends across continents, it can be difficult to know exactly where material originated from and whether it meets all international standards for compliance with environmental regulations and honest trade practices. As a responsible buyer, how can you be sure of the integrity of the resources you consume?

Ensure your supplier employs rigorous in-house testing and verification procedures for incoming raw materials. This is the only way to guarantee that the materials used on your project are up to spec, legal and of high-quality. And some markets require proof that your products contain no banned substances like lead or cadmium, as with RoHS regulations in Europe. A responsible supplier will have no problem providing verification that will give you complete peace of mind.

In the global marketplace, you want to be a good global citizen. So be wary of any supplier who can’t or won’t give you this degree of confidence that they take their responsibilities seriously.

The Benefits of Globalization in Manufacturing

Globalization continues to make possible the worldwide exchange of new technologies, finished goods and even new ideas.  The pace of change is ever-increasing, so to keep up with it requires careful planning, foresight and working with the right manufacturing partners. If you want to take full advantage of the expansion of global trade you should look for companies that are flexible, rapid to respond to changing conditions, and above all demonstrate a commitment to providing world-class service and support. Those are universal values that will always be sought after in a global marketplace. When you contact us for a free quotation and project review, you’ll receive this same level of service and much more.

Plastic Manufacturing Guide: Types of Plastics and its Processes

Plastics are now a necessary component of everything from consumer goods to medical equipment. The plastics industry encompasses a wide range of plastic types and production techniques.

This article aims to give readers a comprehensive understanding of plastic manufacturing processes and the types of raw materials. Here, we’ll also discuss how to choose the right manufacturing method for plastic projects as well as selecting the right plastic part manufacturer for your project.

Contents
hide

I
Key Manufacturing Procedures for Plastic Products

II
Common Materials Used in Plastic Manufacturing

III
Main Types of Plastic Manufacturing Processes

IV
How to Choose the Right Manufacturing Methods for Plastic Projects?

V
How is Quality Control Maintained in Plastics Manufacturing?

VI
Considerations and Tips to Find a Reliable Plastic Product Manufacturer

VII
From Idea to Reality: Choose WayKen for Plastic Part Manufacturing

VIII
Conclusion

IX
FAQs


Key Manufacturing Procedures for Plastic Products

There are multiple steps in the production of plastics, and these steps ensure the production of quality plastic parts. Preparing the materials, polymerizing them, adding additives, molding, and finishing are the important processes. Let’s discuss these processes in detail.

Material Preparation

Material preparation is the initial stage in the plastic manufacturing process. This entails the extraction and refining of raw materials. The main raw materials used in the production of plastics are hydrocarbons, which come from coal, natural gas, and petroleum.

Polymerization

Polymerization is the method used to create plastic polymers. The type of polymerization technique used is often dependent on the type of plastic being made. For instance, polyethylene and polypropylene are produced through addition polymerization, although nylon and polyester are formed through condensation polymerization.

Additives

The addition of additives occurs after polymerization to improve the quality of the plastic produced. These additives can enhance the color, strength, flexibility, resistance to heat and UV rays, and other properties of the plastic.

Stabilizers, colorants, flame retardants, and plasticizers are examples of common additives. The final product’s intended qualities determine the type and quantity of additives utilized.

Molding/CNC Machining/3D Printing

The plastic takes on its final form during the molding process. Several molding processes are employed in the production of plastics, including rotational molding, blow molding, extrusion, and injection molding. The choice of molding technique is influenced by the type of plastic, the intricacy of the component, and the volume of production. For example, extrusion is best used to create long, continuous shapes, whereas injection molding works well for producing complex pieces in large quantities.

Where precision, accuracy, and tight tolerance are important, CNC plastic machining is ideal. Also, some plastic materials such as Delrin, Acrylic, and PEEK are better manufactured using CNC machining. On the other hand, if complex internal structural parts need to be machined, 3D printing is ideal, the 3D printer is used in layering plastic material until the product achieves the desired shape.

Finishing

Finishing is the final phase of the plastic part manufacturing process. It usually involves any post-processing actions required to give the part the desired look and functionality. Drilling, painting, printing, coating, and polishing are examples of finishing procedures. The type of finishing technique employed depends on the finished product’s needs. For instance, painting may be necessary for plastic parts used in automobiles to match the color of the vehicle.

Common Materials Used in Plastic Manufacturing

For the production of robust, long-lasting, and adaptable goods, the plastics industry uses a variety of raw materials. The most commonly used plastic manufacturing products are PC such as ABS and other plastics.

Polypropylene (PP)

Polypropylene is a sturdy, heat-resistant plastic used for manufacturing consumer goods, automotive parts, and packaging. PP is well-known for its capacity to remain stable and in its original form at elevated temperatures, making it perfect for use in the electronics and automotive sectors.

Polystyrene (PS)

Polystyrene is an inexpensive, lightweight plastic frequently used to make consumer goods, insulation, and packaging. It’s a popular choice in many industries because of its inexpensive cost, ease of production, and insulating qualities.

Polyethylene (PE)

Polyethylene is a popular plastic for manufacturing consumer goods, medical devices, and home appliances. This plastic is strong, lightweight, and adaptable, coming in various forms including LDPE, HDPE, and LLDPE.

Polyvinyl Chloride (PVC)

PVC is a durable and adaptable plastic frequently utilized in flooring, electrical, and plumbing applications. It is a common material for construction applications because of its affordability and reputation for being resistant to chemical deterioration.

Polyethylene Terephthalate (PET)

It is a popular plastic for food packaging, drink containers, and fabrics that are lightweight and resistant to breaking. PET is the perfect material for packaging food and beverages because of its high transparency, low gas permeability, and lightweight nature.

Acrylonitrile Butadiene Styrene (ABS)

ABS is a tough, impact-resistant plastic frequently used in toys, consumer products, and vehicle parts. Because of its excellent impact resistance, ABS is used in products often subjected to frequent impact or harsh handling.

Polymethyl Methacrylate (PMMA)

PMMA commonly recognized as acrylic, functions as a transparent thermoplastic that often serves as a lightweight, resilient substitute for glass. An outstanding feature of PMMA lies in its exceptional clarity and light transmission properties, making it well-suited for applications where visibility is paramount.

PEI (Polyetherimide)

Polyetherimide (PEI) stands out as an advanced thermoplastic renowned for its exceptional thermal stability, mechanical robustness, and resistance to chemicals. Applications of PEI span various industries, including automotive, aerospace, and electrical engineering, where components must endure extreme conditions while upholding structural integrity.

Main Types of Plastic Manufacturing Processes

Numerous plastic part manufacturing processes are widely used because of their advantages and versatility in producing a variety of goods. Here, we discuss the various plastic manufacturing processes.

CNC Machining

CNC machining is a process that creates the required object by removing material from a solid block using computer-controlled, fast-rotating tools. This subtractive process is perfect for prototypes and precision components, used in different industries because it offers great precision and works with a wide range of polymers such as Delrin, Nylon, Acrylic, and Polyether ether ketone (PEEK).

3D Printing

Using a digital model as a guide, additive manufacturing, sometimes known as 3D printing, creates items by layering material. It’s perfect for the low-volume manufacture of complex plastic parts and prototyping because it’s rapid and versatile. The most common plastic materials used for 3D printing are Acrylonitrile Butadiene Styrene (ABS) and Polylactic Acid (PLA).

Injection Molding

Plastic injection molding is a widely used method in the production of plastic components. The process entails melting plastic granules and then pumping them into a mold at high pressure. When the plastic cools and solidifies, the mold opens to release the produced part. Because of its material efficiency and reproducibility, this method is perfect for mass-producing intricate, high-precision parts.

Extrusion

The plastic extrusion process is a continuous technique used to make pipes, profiles, and sheets, among other goods having a uniform cross-section. After melting and forcing the molten plastic through a die with the required cross-section, cooling and cutting occur. Although it works well for producing long, straight sections, it is not the best method for producing complex or intricate shapes.

Thermoforming

Thermoforming involves heating a flat sheet of plastic until it becomes flexible, at which point it is formed into the shape of a mold by vacuum pressure. The sheet keeps its molded shape once it cools. The plastic materials ideal for use in thermoforming include polypropylene, polyvinyl chloride (PVC), polycarbonate (PC), Polymethyl methacrylate (PMMA), etc.

Blow Molding

One method of making hollow plastic parts or components is blow molding. The plastic is first melted and then formed into a preform. The next step is putting the preform into a mold and air blasting it to make the plastic expand. This technique is frequently applied to other hollow structures, such as bottles and containers.

Compression Molding

During the compression molding process, a preheated plastic material is inserted into an opened, heated mold chamber. After closing the mold, pressure, and heat are applied to the material until it completely assumes the shape of the mold. It works well for large items like electrical housings or car panels and is used with thermosetting materials.

How to Choose the Right Manufacturing Methods for Plastic Projects?

Many factors influence the choice of appropriate plastic production techniques. These variables include the part’s shape, the cost and volume of production, lead time, and properties of the product or material.

Part Design

The chosen manufacturing process is largely determined by the part’s physical geometry or form. CNC machining and Injection molding are the common processes for producing intricate shapes with precise tolerances. They’re great for the production of parts with complicated shapes and detailed features.

For plastic parts with intricate interior geometry, 3D printing is another choice, as it prints parts with high precision and accuracy.

Production Volume

The most economical and appropriate manufacturing method for plastic parts is largely determined by the volume of output. Due to their flexibility and reduced upfront costs, techniques such as 3D printing and CNC machining are ideal for low-volume manufacturing of plastic.

In medium-volume applications, silicone molding offers a scalable solution by balancing the cost per unit with the initial tooling expense. For high-volume manufacturing, injection molding, and extrusion stand out as the ideal methods because they minimize the cost per unit and guarantee consistent quality in large volumes.

Cost

Cost is one major factor that influences the choice of manufacturing process. In high-volume manufacturing runs, processes like plastic injection molding have lower per-unit costs due to their greater upfront tooling costs. In low-volume manufacturing runs, processes like vacuum forming and 3D printing usually have higher per-unit costs because of their lower upfront expenses.

Lead Time

There is another important consideration is lead time or the production rate. Opting for a technology with a short lead time, such as 3D printing, could be a wise decision if the product needs to be launched promptly. Though they provide better economies of scale for high-volume production, processes like injection molding could be appropriate if longer lead times are acceptable.

Material Features

Certain kinds of materials are better suited for particular manufacturing techniques. For example, with thermoset and thermoplastic differences, compression or injection molding is ideal for creating thermosetting polymers, which harden permanently following an initial heat form.

The physical attributes of the product such as its flexibility, resilience to impact, transparency, and tolerance to temperature changes also influence the selection of the manufacturing process. For instance, techniques that offer high degrees of precision, like CNC machining, might be selected if a product needs to adhere to exact specifications with strict tolerance standards.

How is Quality Control Maintained in Plastics Manufacturing?

In the plastics industry, quality control is essential for generating reliable, high-quality goods. It entails a series of tests, inspections, and processes to ensure that every component meets the required standards.

Material Quality and Consistency Checks

Testing plastic materials for characteristics like tensile strength, color consistency, and melt flow index guarantees that the material will fulfill end-use criteria and behave reliably during manufacturing. This stage is to avoid problems with the finished product, such as brittleness, warping, or failure under stress.

Process Parameters Control

Controlling the parameters of the molding process is for ensuring quality in the production of plastic parts. This entails monitoring the injection pressure, mold temperature, cooling period, and cycle time to ensure that no component is created with flaws like sink marks, warpages, short shots, or burns.

To guarantee that every plastic part meets stringent quality standards, automated process monitoring systems can assist in maintaining these parameters consistently during each production cycle.

Quality Assurance Testing

Completed plastic parts must undergo extensive quality assurance testing to ensure that they meet all criteria and standards. The structural integrity, dimensions, and performance characteristics of the parts are verified using testing techniques such as mechanical testing, dimensional analysis, and environmental testing.

Before releasing plastic products into the market, manufacturers can ensure that they are reliable and functional through comprehensive quality assurance testing.

Considerations and Tips to Find a Reliable Plastic Product Manufacturer

A reliable plastic product manufacturer should not only produce quality products but also deliver these products in a timely manner. Here are tips and considerations when looking for a plastic product manufacturer.

Material Availability

There are different materials used for making plastic parts. It is important to note that not all manufacturers offer these materials or can make parts using them, which is why it is often best to conduct research on plastic manufacturers before committing to one.

Manufacturing Capability

The question to ask here is: Is the manufacturing company equipped with the type of technology required for high-performing plastic fabrication? Do they use dependable plastic materials? Also, what technique or manufacturing process does the manufacturer employ in making plastics? The answers to these questions will help you decide if that particular manufacturer is ideal for your product.

Production Capacity

What is the scale of your production? Are you making prototypes, small production runs, or large-scale production runs? It is best to choose a plastic manufacturer that offers extensive product development; from prototyping to large-scale production, as this makes scaling easier.

Production Cost

Production cost is an important consideration when selecting manufacturers for your project. True, several factors go into the final price, including the cost of raw materials and volume produced, but labor costs also influence the cost. It is best to go for manufacturers that offer affordable pricing as well as a wider range of services.

From Idea to Reality: Choose WayKen for Plastic Part Manufacturing

WayKen offers comprehensive machining solutions to meet all of your plastic production needs, including CNC machining, injection molding, 3D printing, and so on. From prototyping to production, our reliable services bring your ideas to life efficiently and effectively.

In addition, With more than 30 engineering plastics, we specialize in CNC plastic machining with complex geometry and high precision to meet your strict specifications. Upload your CAD files and get a quote today!

Conclusion

A variety of methods, each with its own advantages and disadvantages, are available for creating plastic parts in the plastic manufacturing sector. When choosing a manufacturing process, it is crucial to carefully weigh each of these considerations to guarantee that the finished product will satisfy all criteria and be produced in a timely and cost-effective manner.

FAQs

What is the role of automation in plastic manufacturing?

The use of automation technology in the plastics industry can improve quality, productivity, and efficiency. Automated systems can increase the precision and accuracy of plastic production processes, producing parts and components that are more dependable and consistent.

What is the most common process for plastic manufacturing?

Injection molding is the most widely used method in the production of plastics. It is a common practice to employ injection molding to create a wide range of plastic parts, from complex pieces to substantial items.

What are the types of plastics used in plastic parts manufacturing?

Due to their ease of processing and adaptability, thermoplastic polymers like polyethylene and polypropylene are commonly used in the fabrication of plastic parts. For specific purposes, thermosetting materials with excellent heat resistance and durability, such as epoxy resin and phenolic resin, are also used.

Keyword: cnc turning

云原生世界中的 API 安全

API(应用程序编程接口)已经存在了几十年。它们是系统和应用程序之间交换信息的默认媒介。随着最近云原生应用程序(使用依赖 API 的互连服务进行架构和构建)的出现,API 已经变得无处不在 – 成为我们在线世界的道路和高速公路,并且是我们现在依赖的许多服务不可或缺的一部分。

攻击者为何瞄准 API

开发人员采用 API 优先的方法来构建应用程序、工具和流程。但是,当开发人员为应用程序构建、管理、发布和利用 API 时,安全团队在了解如何保护 API 免受其独特配置和使用所固有的风险方面往往落后了十步。

黑客们意识到了这种延迟。缺乏安全控制,再加上 API 使用量和流量的增加,使得 API 成为恶意攻击者的主要目标,他们寻找漏洞和 API 错误配置来访问应用程序内的宝贵数据和资源。

例如,最近 Optus 发生的一起泄露 1000 万个客户账户的事件就涉及一个面向互联网的 API,该 API 无需授权或身份验证即可访问客户数据,就是这么简单。

就这么简单?

了解您的云工作负载中包含哪些 API 非常复杂,尤其是考虑到基于云的应用程序开发速度。开发团队通常发现跟踪新的和更改的 API 几乎是不可能的。此外,应用程序的复杂性会导致配置错误,以及产生漏洞的不受管理且不安全的 API。事实上,Gartner 预测,到 2025 年,只有不到 50% 的企业 API 得到管理。

许多 API 网关和监控解决方案无法识别风险或防范针对 API 的OWASP Top 10攻击。添加另一个工具来解决 API 安全问题只会增加安全和开发团队的成本和复杂性。

Prisma Cloud 的 API 安全方法

Prisma Cloud 作为其全面的云原生应用程序保护平台 (CNAPP) 的一部分,为所有 API 提供完整的 API 发现、风险分析和实时保护。

API 安全功能:
  • API 发现:自动发现您环境中的所有 API,并消除由影子 API 或恶意 API 造成的盲点。
  • API 风险分析:识别 API 风险、风险因素(基于风险因素,例如配置错误、敏感数据暴露和访问控制),并确定补救措施的优先级。
  • 实时保护:针对 OWASP Top 10 API、速率限制和恶意机器人的攻击实施实时保护。

整体大于部分之和这一说法也适用于平台产品。点解决方案作为不相连的部分,通常会带来更多工作,并导致与可见性有限相关的问题。

通过将 API 安全性融入 Prisma Cloud 的 Code-to-Cloud CNAPP,我们能够使用更少的工具提供更好的安全性。组织可以通过单一解决方案获得 API、应用程序、工作负载和基础设施的全面安全性。

API 发现

无法保护无法找到的东西。缺乏 API 文档会给不了解 API 使用原因的安全团队带来障碍。有关正在运行的 API 的信息对于保护它们免受滥用至关重要。在绘制此图时,重要的是找到所有 API 通信并收集尽可能多的有关影子 API 和恶意 API 的信息。

API 发现是保护 API 的第一步。Prisma Cloud 为所有 API 提供自动化 API 发现功能,包括南北 API(互联网到微服务)和东西 API(微服务到微服务)。用户能够将数据导出为 OpenAPI 规范,可将其用作 API 保护的基准。

API 观察和安全团队

每个 API 端点都会对应用程序及其数据造成不同的风险。各种因素都会影响总体风险,每个因素都有各自的权重,例如敏感数据暴露、缺少授权和访问控制。安全团队需要了解与 API 和底层工作负载相关的所有风险因素,以确定风险的优先级并采取主动措施。

Prisma Cloud 可帮助团队识别 API 风险、风险因素并确定补救措施的优先级。通过在开发和构建期间扫描 API 定义文件,开发人员可以在 API 投入生产之前防止其配置错误、结构不当和模式不正确。

实时保护

OWASP 安全项目指出,“API 安全侧重于了解和缓解应用程序编程接口 (API) 特有漏洞和安全风险的策略和解决方案。”但是,许多声称为 API 提供实时或运行时保护的 API 安全解决方案仅提供可见性。而没有保护的可见性并不是安全性。

在理想情况下,API 安全性从 API 构建时开始,并持续到运行时。Prisma Cloud 很自豪能够为您的 API 提供实时保护,以抵御 OWASP Top 10 for API 中的攻击以及速率限制、恶意机器人等。

此外,我们还提供可自定义的规则,因此团队可以根据其特定场景和环境定制规则。用户还可以启用我们的威胁研究团队针对已知漏洞创建的虚拟补丁,这样您就可以修补应用程序,并让您的团队有时间修复漏洞。

API 风险分析

由于应用程序开发速度快,如果没有自动化,跟踪与 API 相关的风险将非常困难。但是,API 安全首先要全面了解 API 在云环境中带来的风险。

Prisma Cloud 的冬季版本通过 API 风险分析增强了 API 安全功能。此新功能可帮助团队根据环境中所有 API 的 200 多个因素了解和确定风险优先级。现在,您可以最大限度地减少 API 攻击面,并根据风险因素(例如配置错误、敏感数据暴露和缺乏身份验证)管理保护。

文章来源:API Security in a Cloud-Native World

Keyword: kimi api

Five Stunt Evo 2 Women's Gloves

 

This is clearly the most common, new-gen iteration of the STUNT concept invented by FIVE. Its topside construction in tough stretch Twill Span fabric contributes greatly to the exceptional comfort of this iconic style. It features exceptional protection, given the second-skin feel it offers, with its AirgoProtech™ shells inspired by helmet technology (see previous pages), featuring a particularly innovative design. Its 100% full-grain goat leather palm, which is both supple and durable, feels so smooth and soft to the touch…And yet, it offers excellent grip on the controls and hosts a leather reinforcement lined with an ERGO PROTECH® semi-soft, honeycombed protective shell that offers a reassuring feeling of safety, without hindering your movements in any way. With its signature look, the STUNT EVO2 offers its rider a certain kind of status: that of an avant-garde design aficionada, even offering the feeling of being truly on the cutting edge, even ahead of the curve.

 

FEATURES

  • Twill Span stretch topside construction
  • Full-grain goat leather palm 
  • Ventilated AirgoProtech™ metacarpal-knuckle protector 
  • ERGO PROTECH® honeycombed palm slider
  • TPR finger protection with air intake vent
  • Softshell thumb construction for optimal finesse and comfort
  • Ultra-tough stretch Nylon fourchettes between the fingers
  • Ergonomic, fused neoprene wristband with integrated velcro closure
  • Touch Screen™ system on the index finger and thumb
  • CE KP1

Related Products

Five Stunt Evo Airflow Women's Gloves



Skip to product compare


sale

Five Stunt Evo Airflow Women's Gloves


Starting at
$61.95


MSRP Price
$124.95

Save 50% Off MSRP

Five Sport City Women's Leather Gloves



Skip to product compare


sale

Five Sport City Women's Leather Gloves


Starting at
$111.96


MSRP Price
$139.95

Save 20% Off MSRP

Five Mustang Evo Women's Gloves



Skip to product compare

Five Mustang Evo Women's Gloves


Starting at
$79.95


MSRP Price
$95.95

Save 17% Off MSRP

Five Kansas Women's Gloves



Skip to product compare


bestsellers

Five Kansas Women's Gloves


Starting at
$98.96


MSRP Price
$109.95

Save 10% Off MSRP

Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired

Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products

William M. Hewitt, Siegfried S. F. Leung, Cameron R. Pye, Alexandra R. Ponkey, Maria Bednarek, Matthew P. Jacobson, and R. Scott Lokey, J. Am. Chem. Soc., 2015137, 715-721.

Drug design efforts are turning to a new generation of therapeutic targets, such as protein–protein interactions (PPIs), that had previously been considered “undruggable” by typical small molecules. There is an emerging view that accessing these targets will require molecules that are larger and more complex than typical small molecule drugs. Here, we present a methodology for the discovery of geometrically diverse, membrane permeable cyclic peptide scaffolds based on the synthesis and permeability screening of a combinatorial library, followed by deconvolution of membrane-permeable scaffolds to identify cyclic peptides with good to excellent passive cell permeabilities. We use a combination of experimental and computational approaches to investigate structure-permeability relationships in one of these scaffolds, and uncover structural and conformational factors that govern passive membrane diffusion in a related set of cyclic peptide diastereomers. Further, we investigate the dependency of permeability on side-chain identity of one of these scaffolds through single-point diversifications to show the adaptability of these scaffolds toward development of permeability-biased libraries suitable for bioactivity screens. Overall, our results demonstrate that many novel, cell permeable scaffolds exist beyond those found in extant natural products, and that such scaffolds can be rapidly identified using a combination of synthesis and deconvolution which can, in principle, be applied to any type of macrocyclic template.

Quality Nightmare Due To Lack of Post-Harvest Care – Botry

Botrytis is an airborne fungal disease that can affect all flower, fruit and vegetable tissues. Starting as a little while speck on the flower petals, it spreads right to the bottom of the flower. It gradually changes its colour to brown and finally all the petals fall off.

Botrytis blight or “gray mold” is a widely distributed disease caused by the fungus Botrytis species. Botrytis is an airborne fungal disease that can affect all flower, fruit and vegetable tissues. Starting as a little while speck on the flower petals, it spreads right to the bottom of the flower. It gradually changes its colour to brown and finally all the petals fall off.

Peonies and Roses are the most likely plants to show signs of botrytis. Other flowers, such as Chrysanthemum, Gerbera and Lisianthus are also very attractive to the Botrytis fungi.

Unfortunately, horticulturists haven’t developed any botrytis-resistant flower species. Gardeners must continue to battle this tenacious fungal flower disease by practicing good garden and greenhouse hygiene and cultural practices.

To minimize botrytis:

  1. Keep your flowers dry (the buds and petals). Do not spray water or allow water to drip onto the Flower heads
  2. Remove infected flower petals  or the entire bud and stem when required. This will keep botrytis from spreading to the rest of the flowers in a vase or arrangement.
  3. Do not leave flowers in their sleeve or wrap any longer than necessary. If condensation builds up in the sleeve or wrap, open the bunch, wipe moisture off of wrap, fluff up the blooms and allow them to dry a bit before re-wrapping.
  4. Keep good air circulation

When discussing fresh cut flowers and how to help them reach their maximum potential an extremely critical part of the cycle are the methods and techniques of Post-Harvest Care that are used starting at the time of cut. Too often flowers are harvested at the farms and transported to retail outlets only to be subjected to poor or non-existent post-harvest care when they arrive.

Strict adherence to the latest in Post-Harvest Care methods and treatments is a must. Fresh Cut Flowers prefer a clean environment and require proper nourishment, under these conditions they flourish.