De l'étude du génome à la crème anti-âge: les "omiques" appliquées à la cosmétique

D’où vient une peau sèche ? Que se passe-t-il quand la peau vieillit ? Pourquoi a-t-on des pellicules ? Les sciences “omiques“ se sont invitées au 28e Congrès mondial des sciences cosmétiques, cette semaine à Paris.

La cosmétologie a recours aux omiques pour comprendre les mécanismes cellulaires de la peau.

Tout a commencé par un suffixe ajouté au mot gène: la génomique, l’étude de l’ensemble des gènes, était née, fille aînée de la famille des “omiques“ (omics en anglais), des technologies utilisées par la recherche biomédicale, l’industrie du médicament, mais aussi la cosmétique.La cosmétologie a recours aux omiques pour comprendre les mécanismes cellulaires de la peau et identifier des “cibles“ d’action pour la mise au point de nouveaux produits.“Ce sont des technologies qui donnent accès aux différents composants du vivant“, explique à l’AFP Dominique Bernard, responsable de la plateforme Omics chez L’Oréal Recherche et Innovation. “Depuis l’ADN, jusqu’au métabolite, c’est-à-dire la petite molécule produite par l’activité de la cellule“.L’utilisation des omiques a explosé avec le développement de techniques puissantes d’analyse, comme les puces à ADN.Ces outils de biologie moléculaire, qui reposent toujours sur une approche globale, sont désignés grâce à des néologismes formés sur le même modèle, tout au long de la chaîne des composants du vivant.La transcriptomique analyse comment un génome est traduit en protéines grâce aux ARN messagers (acide ribonucléique messager). La protéomique explore l’ensemble des protéines produites par un génome. La métabolomique se consacre à l’ensemble des métabolites d’une cellule.La peau, “très accessible“La complexité augmente à chaque fois : on parle de 21.000 gènes, mais on arrive à plusieurs centaines de milliers de protéines“, souligne le biologiste.Les omiques peuvent ainsi générer des masses d’informations sur la biologie de la peau et du cheveu. La difficulté pour les industriels est d’arriver à en sortir les éléments pertinents pouvant conduire à la mise sur le marché d’un produit qui arrive à satisfaire le consommateur.“Nous devons créer des systèmes bioinformatiques capables d’extraire les informations les plus utiles de ces big data pour pouvoir, par exemple, analyser les différents types et sous-types de peau à travers le monde“, explique Dominique Bernard.“Nous cherchons aussi à trouver ce que nous appelons des +cibles+, parce que quand vous avez identifié une cible, vous pouvez développer de nouvelles molécules capables de moduler cette cible, et donc développer de nouveaux produits cosmétiques“, poursuit-il. Par exemple de nouveaux actifs anti-âge.Le vieillissement est d’origine multiple. Les technologies omiques vont permettre de déterminer des “signatures“ spécifiques à certains types de vieillissement, chrono-vieillissement ou photo-vieillissement, dû à une exposition répétée au soleil. Puis de sélectionner des actifs pour essayer de “compenser“ ces signatures.“Ce qui est merveilleux avec la peau, c’est qu’elle est très accessible“, relève le biologiste. “On a accès à sa surface et on peut déjà en tirer de nombreuses informations sans avoir à être invasifs“.La sueur est aussi une source précieuse d’informations pour les industriels de la cosmétique.“Si vous connaissez la composition de la sueur, vous pouvez proposer un maquillage qui tient durablement sur la peau“, indique Claudie Willemin, présidente de la Société française de cosmétologie, organisatrice du congrès.“Vous pouvez développer des produits qui évitent à la peau de briller, par exemple pour les pays avec un fort niveau d’humidité“, ajoute-t-elle.Les scientifiques s’intéressent aussi de plus en plus au microbiome, ces centaines de millions de micro-organismes, comme les bactéries ou les champignons, présents à la surface de la peau et avec lesquels les cellules humaines “dialoguent“ en permanence.Le Congrès mondial des sciences cosmétiques se tenait de lundi à jeudi au Palais des congrès, à Paris. Il a rassemblé 1.500 participants venus de 40 pays.Source : Relaxnews

Malade en pleine nuit : une campagne de sensibilisation pour savoir qui contacter

L’Agence régionale de santé d’Ile-de-France lance une campagne de sensibilisation auprès des Franciliens pour les inciter à contacter le 15 avant de se déplacer aux urgences des hôpitaux.

L'Agence régionale de santé d'Ile-de-France veut inciter les Franciliens à contacter le 15 avant de se déplacer aux urgences.

03H00 du matin, crise d’angoisse ou crise cardiaque ?“, “Samedi 17h, petite gastro ou crise d’appendicite aiguë ?“, “25 décembre 9h00, petit bobo ou grande urgence ?“… La campagne de l’ARS Ile-de-France veut inciter les Franciliens à composer le 15 avant de se rendre aux urgences. Une campagne qui intervient après qu’une enquête ait révélé le

manque de connaissances des Français quant aux missions du Samu et alors que la grève de certains syndicats de médecins continue.Les différentes missions du SamuLe 15 est le numéro à composer en cas d’urgence vitale, mais pas seulement. Il permet aussi à des personnes confrontées en pleine nuit, les week-ends ou jours fériés à des problèmes de santé imprévus d’être mis en relation avec des médecins. Elles reçoivent des conseils, voire des ordonnances faxées à la pharmacie de garde ou sont orientées vers un “consultation dans un lieu fixe de garde, une visite à domicile ou un recours à l’aide médicale urgente“, rappelle l’Agence régionale de santé (ARS) d’Ile-de-France dans un communiqué.Eviter les passages aux urgences inappropriésAffichettes sur le mobilier urbain, encarts dans la presse et prospectus dans les cabinets médicaux, mairies et hôpitaux de l’Assistance publique-Hôpitaux de Paris (AP-HP), vont être diffusés à partir de mi-janvier et durant tout le premier trimestre 2015, précise l’ARS.L’objectif est “d’éviter les passages aux urgences inappropriés tout en assurant la qualité et la sécurité de la prise en charge des usagers“, indique l’ARS Ile-de-France qui “souhaite renforcer chez les Franciliens le réflexe d’appeler avant de se déplacer“.Outre informer les usagers sur les missions de régulation médicale et d’orientation des Centres 15, l’ARS entend aussi leur faire connaître, par département, les associations de médecins de garde disponibles, via notamment le site 

medecinsdegarde.org.En 2012, 18 millions de passages ont été enregistrés dans les services d’urgences en France, dont 3,5 millions étaient évitables, selon la Cour des comptes. Réorienter ce cas vers les médecins de ville pourrait représenter environ 500 millions d’économies par an à l’Assurance maladie, selon cette source.AFP/RelaxnewsSource : COmmuniqué de l’ARS Ile-de-France – janvier 2015

Pipeline, Mine Work Sites Deemed Essential Services Worry Some Canadians

People who live in remote and Indigenous communities across Canada are questioning the classification of industrial projects like mines and pipelines as essential services, especially when it appears the “business as usual” approach goes against advice to physical distance as much as possible during the pandemic.

Delee Nikal, a Wet’suwet’en band member of the Gitdumt’en clan from the Witset First Nation, travelled to Houston, B.C. for a grocery run last weekend. It’s in the Bulkley Valley, population 3,600, close to construction for Coastal GasLink’s liquified natural gas (LNG) pipeline project. 

She noticed a lot of trucks in a hotel parking lot and was appalled at what she saw.

“There were guys all over there. Some were standing outside, shirtless, drinking beer with each other,” Nikal told HuffPost Canada. Their out-of-province licence plates and heavy-duty gear led her to suspect they were pipeline workers. “It’s scary because they have no connection to us locals — they don’t care.”

Her uncle, Chief Dsta’hyl, whose English name is Adam Gagnon and is a wing chief of Sun House of the Laksamshu Wet’suwet’en clan, wants the pipeline work shut down. He disagrees with authorities defining industrial projects as essential services, a designation determined by provincial and territorial governments.

“They’re committing economic treason,” said Gagnon.

In Valemount, about 600 kilometres east of Houston, CN is shipping in over 100 workers next month to complete annual maintenance on its railway tracks, according to “John,” a CN maintenance worker. He requested anonymity due to job security concerns. The influx would increase Valemount’s population of 1,000 by 10 per cent.

“I’m trying to follow protocols as much as I can,” he said. “But it’s business as usual for the big industry players. Physical distancing is impossible to impose in certain working conditions here.”

John said that during morning safety meetings, at least 25 workers are tightly packed into a small space and move through a narrow hallway, often touching shoulders while walking. He can’t keep two metres from his main co-worker because they travel in the same vehicle and eat their meals in it. 

“[Prime Minister Justin] Trudeau and health ministers are telling people to stay home and not touch their face — so how does that work? Because this whole industry world isn’t abiding by the same rules.” 

In such rural areas, temporary workers and locals shop in the same stores, or employees live with others in the community, so the risk of transmission cannot be avoided. 

On Monday, officials said seven B.C. workers tested positive for the novel coronavirus after returning from an oilsands project in northern Alberta. In High River, Alta., located south of Calgary with a population of 14,000, there are now 358 confirmed COVID-19 cases linked to an outbreak at the local Cargill meat-packing plant

John said he’s thought of quitting, but it’s a difficult choice between work and health when he has bills to pay. He said he’s not worried for himself as much as others in the region if there was an outbreak, especially those who are elderly or immuno-compromised.

Nancy Taylor, 70, who lives in the nearby town of Dunster, is avoiding shopping in Valemount for that reason. 

“I think it’s a double standard for all of us in the valley to be socially isolating and sticking to the rules and they (industry) can just come and go,” said Taylor, who is statistically less likely to survive if she contracts COVID-19 at her age.

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However, rail transportation is critical to keeping supply chains going, and shutting work down isn’t possible, even in a pandemic, said CN media relations manager Jonathan Abecassis.

“CN is an essential part of the many supply chains Canadians rely on to get the goods they need. As an essential service in Canada, this includes completing safety critical work to ensure a safe and efficient rail infrastructure,” he said. 

CN’s pandemic plan aligns with the World Health Organization, as well as provincial and federal authorities, Abecassis said. It includes procedures for self-isolation if an employee or someone they live with has symptoms of COVID-19. 

“Employees have also been instructed to respect the protocols in place to maintain a safe working environment, including physical distancing requirements especially as they work in small communities across our network,” he said in an email to HuffPost. 

Adding further pressure on the small community is the expansion of the Trans Mountain pipeline, slated to start construction in the area soon. It plans to bring in 50 employees to begin assembling a work camp south of Valemount, which will have a capacity of between 600 to 900 people.

Manitoba NDP MP Niki Ashton is calling for federal leaders to step in and shut down all industrial projects amid the COVID-19 pandemic.

“Are diamonds and gold really essential services right now? No,” she said, referring to mining operations still running in Canada’s North. 

Industry work camps tend to be in “northern regions, or adjacent or on Indigenous communities that are extremely vulnerable,” said Ashton, who represents the sprawling riding of Churchill-Keewatinook Aski. 

These are ”regions that are completely unprepared to deal with a minimal spread [of COVID-19], let alone a surge. The idea of leaving it up to the provinces, and worst of all, leaving it up to employers whose obviously number one goal here is continued operations for profit …. is in stark contrast to what we need to be prioritizing right now, which is people’s health.”

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Watch: Blackfoot doctor explains how her people are more at risk to the impact of the coronavirus.

 

At a press conference earlier this month, N.W.T. MLA Katrina Nokleby noted, “Safety is our number one priority, but next to that is ensuring that our economy remains healthy and people feel secure.” She expressed confidence in measures taken by resource companies and called them “strong corporate citizens.” 

Public health officials in N.W.T. have ordered mining, oil and gas companies to screen employees entering the territory, and the firms have enhanced cleaning and added physical distancing measures including segregating southern and northern workers, according to Nokleby.

Dominion Diamond Mines suspended operations at its Ekati site in March to “safeguard its employees” during the pandemic, while the Diavik diamond mine, owned by Rio Tinto, remains open with about 500 people on site. 

“Our focus is on the health and safety of our employees and communities, and on keeping our operations running safely so we can continue to contribute to the Northwest Territories economy,” said spokesperson Matthew Klar in a statement to HuffPost. Diavik has changed the frequency of shift roster changes from two weeks to four weeks, and employees from 12 isolated northern communities or who have specific risk factors remain off-site. 

In B.C.’s Bulkley Valley, Coastal GasLink is following guidelines for construction sites and industrial work camps set by the provincial health officer, such as setting a maximum of 50 workers in dining and common areas, and increasing the number of hand-washing stations on work sites. 

But there’s another layer to the concerns over Coastal GasLink’s LNG pipeline project that has faded during the pandemic: hereditary Wet’suwet’en chiefs continue to oppose the construction running through their traditional territory.

Solidarity protests and blockades that shut down many of Canada’s transportation corridors in February built momentum, leading to an intense, three-day emergency meeting between government officials, hereditary chiefs and Wet’suwet’en elected leadership.

Then, the pandemic hit.  

‘They’re out there killing the land’

Nikal and her fellow “land defenders” were forced to isolate on their home reserves to avoid the coronavirus, which First Nations are particularly vulnerable to.

“This is heartbreaking,” Nikal said, of not being able to protect her ancestors’ lands  currently being “dug up” by construction workers. 

“Wet’suwet’en lands are at risk, let alone the people’s health from the coronavirus,” said Kate Gunn of First Peoples Law, who represents Wet’suwet’en hereditary leaders. “Many First Nations and Indigenous communities have to divert their internal capacity to keep themselves safe in this pandemic. They can’t send resources out to protect the land right now.”

It’s business as usual on the near $7-billion project slated to carry LNG through northern B.C. to export to Asian markets. This week, Coastal GasLink announced it completed a construction milestone for the first part of the pipeline route. 

“They’re out there killing the land. The workers and COVID are a huge threat to us now,” said Nikal. 

With files from Samantha Beattie

CORRECTION: A previous version of this story stated that the photos of the work camp inside the Morice River access point in Wet’suwet’en territory were taken in April 2020; in fact, they were taken in the fall of 2019.

Saskatchewan’s Plan To Reopen Economy Could See Stores, Golf Courses, Hairdressers Open In May

REGINA — Dentist offices, hairdressers, golf courses and retail stores could be allowed to reopen starting in May under Saskatchewan’s plan to refire parts of its economy during the COVID-19 crisis.

The five-phase plan presented Thursday includes timelines for when businesses and services shuttered to protect against the spread of the novel coronavirus might be allowed to open their doors.

Premier Scott Moe has said the number of COVID-19 cases will be monitored throughout each phase and the government will only move ahead if the infection rate stays low. In a televised speech Wednesday night, he said health officials are looking to increase testing and contact tracing.

Watch: Saskatchewan plans to reopen economy in May

 

So far, Saskatchewan has reported 326 cases of COVID-19 and four deaths.

Some other provinces are thinking about reopening some parts of their economies as spread of the virus becomes manageable, but Saskatchewan says it’s the first to release a detailed plan with dates and a timeline.

“Some may be concerned that this is far too soon, that reopening businesses in the coming weeks could increase the spread of COVID-19,” Moe told a news conference.

“We have to find the middle ground that continues to keep our case numbers low and keep Saskatchewan people safe, while at the same time allowing for businesses to reopen and Saskatchewan people to get back to work.”

Restrictions are to lift first for medical services such as dentists, optometrists and physical therapy on May 4. That also applies to fishing and boat launches.

Golf courses could be allowed to reopen on May 15, followed on May 19 by retail shops that sell clothing, flowers, books, sporting goods and toys.

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The government says hairdressers, barbers, massage therapists, and acupuncturists could also begin seeing clients again on that day, but employees working directly with customers would have to wear masks.

The plan says businesses would be expected to maintain strict cleanliness standards as well as physical distancing. Operators would be asked to screen clients and wear masks and gloves if those measures were not possible.

Next, officials would consider lifting restrictions on indoor and outdoor recreational and entertainment facilities and bumping up the size of allowable gatherings to 30 people from the current 10.

The final phase of the plan includes lifting restrictions on crowd sizes, visits to long-term care facilities and non-essential travel. Moe has already said those will stay put for some time.

No timeline for gyms

The government’s plan doesn’t provide a timeline for when gyms might be allowed to operate or when daycare capacity might be increased.

Nor does it give a time frame for food services and restaurants to reopen, but when they do, they will be expected to operate at half their capacity.

Moe said he doesn’t see an issue with provinces lifting restrictions at different times and would be speaking to premiers on their weekly call. He said he had already shared the reopening plan with the federal government and some of the provinces.

The premier also said he doesn’t think it would be unexpected to see a small increase in cases. Saskatchewan’s chief medical health officer said transmission of the coronavirus will continue.

This report by The Canadian Press was first published April 23, 2020

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Patriots Surprise Bullied Girl With Super Bowl Tickets

FOXBOROUGH, MA — A New Hampshire girl bullied for playing quarterback was surprised by none other than Julian Edelman with tickets to Super Bowl LIII. When the Patriots learned Dejah Rondeau, a seventh-grader and quarterback for the Exeter Seahawks, was being bullied, they decided to give her the star treatment.

Seacoast Online reported Pats owner Robert Kraft invited Rondeau to Patriot Place in the days following their nail-biting AFC championship victory over the Chiefs.

She wears No. 11 in honor of Edelman, and even got to play catch with the star receiver.

But the Pats weren’t done surprising Rondeau. “Do you have any plans next Sunday?” Edelman joked in a video posted on the Patriots’ website.

“No,” she said, in shock.

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“When Julian pulled out the tickets, I didn’t know what to say. I never in a million years thought I would go to a Super Bowl,” she said, according to Seacoast.

“I heard about your story about going out there and having the challenge of dealing with adversity because of people not accepting this, that,” Edelman said to his biggest fan. “My respect level for you is just through the roof because you just ignored all the noise and played the game we all love.”

See the full Seacoast Online report and their video below:


Photo credit: Seacoast Online YouTube video screenshot

Pilot ID'd In Yorba Linda Plane Crash That Left 5 Dead

YORBA LINDA, CA — The pilot who died when his small plane crashed into a Yorba Linda home was identified as a retired Chicago police officer, investigators said Monday.

Antonio Pastini, 75, was flying the aircraft out of Fullerton Municipal Airport on Sunday afternoon when it made a sudden decline 10-minutes after takeoff, said National Transportation Safety Board Investigator Eliott Simpson.

Radar data indicated that the plane made a left turn and climbed to 7,800 feet, according to Simpson. Witnesses on the ground say the plane “nose-dived” to the ground, and saw the plane’s wings fall off before it struck the ground, NTSB investigator Maja Smith said. Other parts of the aircraft landed across the neighborhood until the 1981 Cessna careened into the home on the 19000 block of Crestknoll Drive.

“Along with the pilot, four individuals died inside the home, two males and two females,” Orange County Sheriff’s Department Carrie Braun said. They have not yet been positively identified.

The Orange County Coroner’s Office is working to positively identify the dead and notify next of kin, she said.

Yorba Linda Plane Crash Sparks House Fire, Kills 5 People: Photos

More than 70 firefighters arrived to battle the home, engulfed in flames. Orange County Fire Authority, Anaheim Fire and Orange Fire Departments responded to the blaze which took several hours to bring under control. One firefighter suffered an ankle injury, according to OCFA Capt. Cameron Rossman.

The National Transportation and Safety Board continues to investigate the cause of the crash, and a preliminary report was estimated to be released within two weeks. The investigation could take up to one year to complete, they said.

Nearby Glenknoll Elementary School was closed Monday during the investigation.

Pastini was the owner of a Carson City, Nevada sushi bar and bestaurant, City News Service has said.

OCFA Photo

What Happened In 1979? The Story Of The Bayerl Cold Case

MUSKEGO, WI — On Feb. 15, 2019, investigators with the Muskego Police Department say they arrested John Bayerl at his Fort Myers, Florida home on suspicion that he was the man responsible for the murder of his ex-wife, Dona Bayerl in 1979.

Over the course of a 40-year investigation, Muskego police never gave up on the case, visiting the Bayerl home to collect evidence and to question citizens time and time again in order to obtain any shred of evidence that could break open the case.

Authorities say they now believe they have the evidence they need to convict John Bayerl, who is now being held in the Waukesha County Jail on a $500,000 cash bond. If convicted, he faces life in prison with no possibility of parole.

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“This is a homicide. It’s a rather unique homicide in that there is no body that has been recovered,” said the court commissioner during John’s initial court appearance this week according to media reports. “The state has detailed that there has been no evidence the alleged victim here has been known of through financial records. She has not turned up anywhere.”

When Wisconsin Patch reached out to local authorities about the key evidence that led investigators to a critical break in this case, they politely declined on the merits that it would jeopardize their ability to prosecute the case.

“We do not want to do anything that will jeopardize the district attorney’s ability to prosecute this case, nor do we want to do anything to interfere with Mr. Bayerl’s ability to receive a fair trial.” Muskego Police Captain David Constantineu told Patch.

Yet there are riveting details to share about the intense police investigation conducted in the spring of 1979.

A criminal complaint filed in Waukesha County Circuit Court this week outlined many of those details.

Here they are as they unfolded:

May 9, 1979: According to a criminal complaint filed in Waukesha County, John reported to the Muskego Police Department, saying that he had an argument with his wife, Dona on the night of May 6, that she left and hadn’t been seen home since.

Police noted that John and Dona lived in their Muskego home with daughters Jodie and Jackie.

May 11, 1979: According to the criminal complaint, police began the early stages of their investigation by questioning Dona’s sister Joan Bourgeois.

Police said Bourgeois felt it was highly unlikely that Dona would leave the home for an extended period of time, and that the marriage between John and Dona had not been going well for quite some time.

Officers questioned John, who, according to police records, told officers that there was no evidence that Dona left the house with the family checkbook.

Officers canvased the neighborhood around the Bayerl family home and find that no fighting was heard by any of the neighbors.

May 13, 1979: Muskego police question John about his missing wife. According to the criminal complaint, John said over the past few years, the communication and the marriage had deteriorated greatly, and that things had been getting worse over the past few months.

According to the criminal complaint, John told police that he and Dona had an argument on May 6, 1979, in which John claimed Dona said “I can’t live like this anymore, or I will go crazy,” and that Dona said she’d be “better off with a boyfriend.”

May 16, 1979: According to police, Dona’s sister Joan Bourgeois said something strange happened on May 7. She told police that John did all of the laundry that day including rugs and a quilt – and that John typically never does the wash, the criminal complaint stated.

May 16, 1979: According to the criminal complaint, Muskego police searched the Bayerl residence again, this time finding what appeared to be spattered blood on the rear service door to the garage. More blood appeared to be located on a child’s seat mounted on the rear of a three-speed bike parked inside the garage.

According to police, when officers told John about the spattered blood, officers on the scene noted that his heart began to beat through his chest as he explained that “he needed clothes.” The rug and quilt were taken to the local crime lab for processing, according to the criminal complaint.

Later that day, police reported questioning John at the police department. During questioning, police said that John admitted that his marriage was “a bad one,” and that he fought with his wife several times.

According to the criminal complaint, John admitted to physically injuring Dona at least six times. The criminal complaint also stated that John admitted to having a girlfriend at the time – a bartender named Diane – that he visited on a weekly basis.

May 17, 1979: Police search the garage of the Bayerl house again, this time collecting blood samples, according to police records.

May 18, 1979: Police question 7-year-old Jodie Bayerl about her parents, according to police documents. She told police that her mother and father fought most of the day on May 6, 1979, according to the criminal complaint.

May 25, 1979: According to police records, officers question Agnes Pascavis, who was John’s first wife from 1962 to 1966.

According to the criminal complaint, Pascavis told officers that John struck or pushed her 15 to 20 times during the course of their marriage and that on one occasion, he choked her. Records also stated that following their divorce, John would continue to harass Pascavis.

July 12, 1979: Police search the Bayerl residence again, this time finding blood traces near the east wall of the house, according to police records. When police asked John the source of the blood found on the basement floor, he told officers that he had cut his finger, according to the criminal complaint.

July 13, 1979: According to the criminal complaint, John admitted to police that he and Dona had been arguing about John’s failure to conduct a car repair and also a television repair on May 6, 1979.

According to police records, John told police he took his family to the Hales Corners McDonald’s for supper, and returned home at 6 p.m. when an argument happened again, lasting until 8 p.m. John said that his wife finished putting the children to bed at 9 p.m. He told police that Dona got her purse, coat and then left the house in her car.

According to the criminal complaint, John told police that he was awoken at 11 p.m. by the sound of a door slamming. He told police that he went to check the house and found Dona’s car in the garage, but no sight of her. According to court records, John told this story to police on July 13, 1979.

August 28, 1979: Dona had gone missing for nearly four months, with no trace. Officers reported that she was not staying with her friend Betty McComb in Michigan, according to records.

May 14: 1980: According to police, a cadaver-searching dog was used by local authorities to see if they could find the body of Dona near the Bayerl family home. The search areas included a wooded area and stream northwest of Sacred Heart Monastery located at Highway 100 and Rawson Ave. and an abandoned farm at W137 S72 Woods Road, a wooded area north of the mail pavilion in the County Park and an entire field and wooded area north of Martin Drive. The search turned up empty.

May 20, 1980: John was granted a divorce from Dona during a court hearing.

June 23, 1980: A search of the Milwaukee County Landfill site at Highway 36 and Rawson Ave. turned up empty, according to police records.

Nov. 28, 1980: John marries for the third time.

July 9, 1981: Police question John’s third wife, Linda Bayerl. According to the criminal complaint, officers say Linda told police that John Bayerl had changed in several ways since their wedding date and had subjected her to physical violence.

According to the criminal complaint, Linda Bayerl told police that John Bayerl had been drinking one day in April, started an argument, pushed and struck her before giving up the assault.

July 14, 1981: According to police records, Linda Bayerl told police that she was leaving her husband John Bayerl out of fear of another attack. She also reported that she discovered that John Bayerl had been using three different social security cards, according to reports.

August 6, 1981: According to the criminal complaint, Muskgeo police serve a search warrant on the Bayerl family house and learn that John Bayerl had multiple counterfeit social security cards.

According to records, a special agent assigned to the case noted that John Bayerl was “very guarded” during questioning and explained that a hand injury of his had been “self inflicted” and that he stabbed his hand intentionally with a scissors.

August 15, 1986: Dona Bayerl is declared legally deceased by a Waukesha County Circuit Court judge.

August 5, 2009: According to the criminal complaint, Jackie Kort recorded a conversation she had with her father, John Bayerl, about her mother, Dona Bayerl.

Police records state that investigators obtained a transcript of the conversation, noting that John Bayerl told his daughter that, “Something happened, and, I, it, I, I’m sure that her heart’s not beating. Because if it was, she would have found her way back, whatever. You know what I mean? I don’t think she’s alive.”

According to the criminal complaint, Kort questioned her father on the night of her mother’s disappearance. According to a transcript cited in the criminal complaint, John Bayerl told Kort, “…somehow something happened when she went for that ride that night and I, I, the car came back, I heard … the doors. Whatever it was, I forget now, it was so long ago.”

July 17, 2018: Police question John Bayerl to update him on the status of their investigation into the disappearance of Dona Bayerl. According to the criminal complaint, police said John Bayerl admitted that he “misused” his wife, and that he was “not a good father and husband and that he blames himself for whatever happened because he was a bad husband.”

According to the complaint, John Bayerl said he “wrote it off in his mind a long time ago,” and that he was “not guilty of anything other than being a bad husband.”

On se prépare pour les 20 Km de Paris

Dans 129 jours, soit le 12 octobre 2014, aura lieula 36 ème édition des 20 Km de Paris. Placé sous le thème de la musique, l’événement est à ne pas rater. Et pour cela, Mizuno met en place un planning d’entraînements rien que pour nous.

Le 12 octobre 2014, Paris se met à la course. Crédit Photo : Didier Lefevre

Depuis 36 ans, des milliers de coureurs arpentent chaque année les rues de Paris pour un 20 Km éreintant, avec départ et arrivée au pied de la Tour Eiffel.Pour être prêt et battre tous les records, le partenaire officiel de la course Mizuno, organise dès le 7 juin des entraînements spécifiques où Benoît César sera le coach sportif. Ce grand athlète, plusieurs fois champion de France, aidera les coureurs de tous les niveaux, avec des entraînements adaptés pour nous mettre dans les meilleures conditions.Pour être prêt le jour J, Benoît César nous donne 9 conseils :1. Avant de débuter toute activité sportive, rendez-vous chez le médecin pour une consultation médicale d’aptitude, le but est de déterminer si le corps est apte médicalement à la pratique de la course à pied.2. Pour les coureurs moyens, ne pas vouloir à tout prix faire des kilomètres pour atteindre son objectif, ce n’est pas la quantité qui prime, mais la qualité. 3 entraînements par semaine sont largement suffisants, mais il faut savoir planifier la préparation en 3 phases (la préparation générale sur 42 jours, la préparation spécifique sur 28 jours et le relâchement avant course sur 2 semaines).3. Il est nécessaire d’adapter son entraînement à son niveau et d’accroître progressivement la charge. Apprendre à écouter son corps et respecter chaque signe de faiblesse.4. Une bonne paire de chaussures est indispensable : adaptée aux appuis, à la morphologie, elle sera utile tout au long de la préparation et pour le jour J.5. L’échauffement est primordial pour éviter les blessures pendant la course à pied, il doit être progressif et proche de la séance qui va suivre.6. Après chaque séance, 10 minutes d’étirements permettent une meilleure élasticité musculaire et ligamentaire. Les étirements doivent être lents, maintenus au minimum 20 secondes, répétés 2 ou 3 fois. Il est important d’étirer les principaux groupes musculaires (antérieur : quadriceps, postérieur : ischios-jambiers, mollets…).7. Boire 1,5l d’eau par jour, il faut absolument s’hydrater avant, pendant et après les entraînements. Ne pas boire pendant un entraînement double le risque de blessure.8. Penser à bien manger. 5 fruits et légumes par jour, pour éviter des crampes : les légumes verts et les fruits sont à privilégier. Limiter les épices et les matières grasses contenues dans la charcuterie et les viandes rouges. Pour éviter les tendinites, le corps a besoin de “bonnes graisses“ contenues dans le poisson, les huiles de colza, noix ou pépin de raisins.9. Dernière chose : toujours prendre du plaisir à ce que l’on fait et quel que soit son niveau. Avec une bonne préparation on arrive toujours à atteindre l’objectif fixé.Ouverts à tous, les entraînements du coach auront lieu du 7 juin au 11 octobre (sauf juillet et août). Pour s’inscrire, direction la page 

Facebook.Anaïs Le HenrySource : communiqué de presse North Communication – juin 2014Click Here: Rugby league Jerseys

Maladies mentales : il est urgent de les prévenir

Mal connues et mal perçues, les maladies mentales sont pourtant fréquentes, chroniques et handicapantes. Outre l’importance du diagnostic et de la prise en charge, la fondation

FondaMental alerte le public, les professionnels et les autorités de santé sur l’urgence de leur prévention, possible à plusieurs niveaux.

Selon la Fondation FondaMental, il est urgent de prévenir les maladies mentales.

Un Français sur 5 concerné mais des idées reçues persistentSelon un sondage IPSOS réalisé en avril 2014 et rendu public aujourd’hui, les maladies mentales toucheraient en France une personne sur cinq au cours de leur vie. Mais les pathologies psychiatriques restent méconnues du public et leur perception, même si elle s’est améliorée depuis un sondage réalisé par le même institut en 2009, a peu évolué.58 % des Français se disent concernés de près ou de loin par les maladies mentales dont 13 % personnellement (+8 % par rapport à 2009). Dans le même temps, une méconnaissance, des craintes et idées reçues ressortent de cette étude. Bien que 56 % des répondants citent la

schizophrénie, 26 % les

troubles bipolaires et 18 % la

dépression parmi les maladies mentales, près de la moitié les associent aux maladies neurologiques comme la maladie d’

Alzheimer ou la

maladie de Parkinson. Certains citent même la

trisomie 21 comme étant une maladie mentale.Concernant les idées reçues et les craintes, 74 % des personnes interrogées considèrent les malades mentaux comme dangereux, plus de la moitié considèrent qu’ils doivent être assistés dans leur vie quotidienne et environ 50 % déclarent qu’ils seraient gênés de vivre sous le même toit qu’une personne atteinte de troubles mentaux.Un besoin d’information manifeste, surtout en matière de préventionMalgré tout, près de 9 Français sur 10 déclarent ne pas se sentir assez informés sur les moyens de prévenir les maladies mentales, alors que 70 % se sentent peu ou pas informés sur les structures disponibles en cas de troubles mentaux, 55 % peu informés sur qui consulter et 78 % peu ou pas informés sur les traitements existants. Pour Leila Idtaleb du département médical d’IPSOS, “ces résultats montrent qu’il existe un paradoxe manifeste car les Français se sentent concernés mais sont peu informés“.

Le Pr Marion Leboyer, responsable du Pôle psychiatrie et addictologie des Hôpitaux Universitaires Henri-Mondor à Créteil et directrice de la fondation FondaMental, précise que, bien que l’image des maladies mentales se soit un peu améliorée par rapport à l’étude de 2009, “tout reste à faire pour informer le grand public sur les facteurs de risque, les signaux d’alerte et les prises en charge disponibles“.Il est urgent de prévenirCes besoins d’information concernent tout particulièrement la prévention “qui est possible, efficace et rentable mais insuffisante en France“, ajoute le Pr Leboyer. A ce propos, le Pr Jean-Claude Etienne, Conseiller au Conseil économique social et environnemental (CECE) souligne que la prévention est un élément essentiel à considérer dans la lutte contre les maladies mentales “qui ne sont pas des maladies différentes des autres“. Pour lui, “malheureusement la prévention a été délaissée dans notre pays, y compris au niveau de la formation des professionnels de santé et cela malgré sa rentabilité économique par rapport au tout curatif“.Le Pr Leboyer insiste sur le fait que la fondation FondaMental en appelle à la mise en œuvre d’une politique volontariste qui aurait comme ambition  le renforcement de la prévention des maladies mentales à trois niveaux :- en prévention primaire, pour éviter le risque d’entrée dans la maladie en identifiant et en prévenant tous les facteurs de risque de trouble psychiatrique (facteurs de l’environnement comme infections, consommation de cannabis, isolement, etc. et facteurs génétiques) ;- en prévention secondaire afin de dépister et prendre en charge le plus tôt possible les maladies n’ayant pu être évitées ;- en prévention tertiaire, pour réduire les risques de rechutes et de handicap à plus long terme.Trois leviers sont à prendre en considération pour améliorer efficacement la prévention des maladies psychiatriques, selon le Pr Leboyer : destigmatiser les maladies mentales et informer le grand public et sur ce point, des grands besoins restent à combler ; promouvoir une psychiatrie spécialisée ; soutenir la recherche pour mieux diagnostiquer, mieux connaître les maladies et leur impact médical, économique et social et mieux comprendre les mécanismes à l’origine de ces maladies.Les Centres Experts FondaMental, des plateformes de diagnostic et de rechercheLa fondation FondaMental a mis en place des Centres Experts qui proposent des offres de soins dans le secteur de la santé mentale. Il s’agit de plateformes de diagnostic et de recherche spécialisées dont 24 sont actuellement opérationnelles en France. Ces centres assurent un dépistage précoce, un diagnostic personnalisé et une évaluation psychiatrique, somatique, sociale et cognitive qui permet le suivi du parcours de soins des patients atteints de troubles bipolaires, de schizophrénie, de

syndrome d’Asperger ou de dépression résistante. Ces centres comportent également des activités de recherche à différents niveaux pour connaître les facteurs de risque, les mécanismes, les biomarqueurs de ces maladies mentales afin, entre autres, d’identifier de nouvelles thérapeutiques, d’évaluer leur coût et l’efficacité de la prise en charge.Des moyens insuffisants, un appel aux donsLes Centres Experts FondaMental couvrent ainsi un très large éventail d’activités mais tous ne sont pas subventionnés. Résultat : dans la mesure où les Centres fonctionnent grâce à des dons faits à la fondation FondaMental, le soutien financier est chroniquement insuffisant. Pour cette raison, la fondation, par la voie du Pr Leboyer, réitère son appel aux dons afin de pouvoir continuer et d’élargir son travail et ainsi améliorer la prévention et la prise en charge des patients atteints de maladies mentales.Dr Jesus CardenasSource : Conférence de presse du 11 juin 2014 “La Fondation FondaMental souligne la méconnaissance des maladies mentales en France et alerte sur l’urgence de leur prévention“. Cette conférence a été organisée à la veille du colloque « Prévention en psychiatrie : les clés de l’efficacité » qui se tiendra à Paris, le 12 juin 2014. Le programme détaillé du colloque est disponible sur le site

www.colloque-preventionpsychiatrie.fr. Les débats de ce colloque seront diffusés en streaming sur le site de la fondation :

www.fondation-fondamental.org.

6 millions de Français ont déjà cuisiné au sans gluten

C’est la tendance phare des nouveaux produits sur lesquels planchent les industriels de l’agroalimentaire : le sans gluten. Un phénomène tel que 6 millions de Français ont déjà essayé de faire la popote à la maison avec des ingrédients sans gluten, révèle une étude BVA/Maïzena.

Même s'ils ne sont pas directement touchés, 4 millions de Français s'intéressent au sujet et se renseignent davantage.

Sept millions de Français se disent concernés par l’alimentation au sans gluten. Parmi eux, 1 million sont intolérants ou allergiques tandis que 2 millions comptent dans leur entourage un proche sensible au gluten. Aussi, même s’ils ne sont pas directement touchés, 4 millions de Français s’intéressent au sujet et se renseignent davantage. Mais, pour mettre en pratique, les choses se compliquent. Car en cuisine, le gluten est vite identifiable. 44% de Français concernés avouent que cuisiner sans gluten est contraignant et pour 52%, celle-ci est plus coûteuse. AFP/RelaxnewsSource : Cette étude BVA/Maïzena a été réalisée sur un échantillon de 1.003 personnes représentatif de la population française âgée de 15 ans et plus. Photo : ©wavebreakmedia ltd/shutterstock.comClick Here: Cardiff Blues Store